The Minnesota Democrat’s colleagues say they expect him to step down on Thursday.
Kevin Kealoha McAleenan is already acting commissioner of U.S. Customs and Border Protection and enjoys bipartisan support.
The Hawaii senator will undergo immunotherapy but said she still plans to seek re-election next year.
Her outspoken opposition to Trump has put the Hawaii Democrat in the national limelight.
The Hawaii senator’s opposition to the nominee for a position crucial to the islands stems from his prior work for the administration.
Campaign finance reports show Hawaii’s U.S. senators have far different totals on hand, but Hirono did raise $400,000 from April to June.
The proposed reauthorization of a housing bill leaves out annual funding of up to $13 million for Native Hawaiians.
Worried Democrats pressed her on what Democrats were doing to battle growing GOP power.
Sen. Brian Schatz, whose term is not up until 2022, has $2.2 million in campaign cash, according to Federal Election Commission records.